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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBX5
All Species:
27.27
Human Site:
S252
Identified Species:
50
UniProt:
Q99593
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99593
NP_000183.2
518
57711
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Chimpanzee
Pan troglodytes
XP_509400
518
57702
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Rhesus Macaque
Macaca mulatta
XP_001111737
518
57694
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Dog
Lupus familis
XP_548568
518
57556
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Cat
Felis silvestris
Mouse
Mus musculus
P70326
518
57813
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Rat
Rattus norvegicus
Q5I2P1
517
57726
R251
L
H
R
M
S
R
M
R
S
K
E
Y
P
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509097
536
59706
L268
K
S
I
M
R
Q
R
L
V
S
T
Q
L
S
T
Chicken
Gallus gallus
Q9PWE8
521
58384
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Frog
Xenopus laevis
Q9W7C2
519
58062
S252
H
R
M
S
R
M
Q
S
K
E
Y
P
V
V
P
Zebra Danio
Brachydanio rerio
Q9IAK8
492
55218
E227
K
I
T
Q
L
K
I
E
N
N
P
F
A
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24432
972
102538
P582
K
L
L
D
V
V
G
P
P
Q
S
P
L
L
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19691
423
46979
K158
T
G
E
H
W
M
S
K
G
A
N
F
H
K
L
Sea Urchin
Strong. purpuratus
XP_797010
645
70075
E343
S
K
M
D
E
L
D
E
E
K
K
D
V
N
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
96.5
N.A.
96.1
95.7
N.A.
53.1
88.4
79.1
70
N.A.
22
N.A.
32.8
31.6
Protein Similarity:
100
99.8
99.8
98.2
N.A.
97.8
98
N.A.
63.6
94.4
85.7
78.9
N.A.
32.7
N.A.
48.2
43.8
P-Site Identity:
100
100
100
100
N.A.
100
6.6
N.A.
6.6
100
100
0
N.A.
13.3
N.A.
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
26.6
100
100
0
N.A.
46.6
N.A.
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
0
8
0
0
0
0
8
0
0
8
% D
% Glu:
0
0
8
0
8
0
0
16
8
54
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% F
% Gly:
0
8
0
0
0
0
8
0
8
0
0
0
0
0
8
% G
% His:
54
8
0
8
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
8
8
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
24
8
0
0
0
8
0
8
54
16
8
0
0
16
0
% K
% Leu:
8
8
8
0
8
8
0
8
0
0
0
0
16
8
8
% L
% Met:
0
0
62
16
0
62
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
8
8
8
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
8
8
0
8
62
8
0
62
% P
% Gln:
0
0
0
8
0
8
54
0
0
8
0
8
0
0
0
% Q
% Arg:
0
54
8
0
62
8
8
8
0
0
0
0
0
0
0
% R
% Ser:
8
8
0
54
8
0
8
54
8
8
8
0
0
8
0
% S
% Thr:
8
0
8
0
0
0
0
0
0
0
8
0
0
0
8
% T
% Val:
0
0
0
0
8
8
0
0
8
0
0
0
62
62
8
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
54
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _